دانشکده پزشکی

موسوي

امتیاز کاربران

ستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعالستاره غیر فعال
 

 
 
دکتر سید هادی موسوی
M.D.  Ph.D. of Pharmacology

 

Name & Surname: Seyed Hadi Mousavi
Date & Place of Birth: 23/8/1974 (1/6/1353) Torbateheydarieh- Iran
Marital Status: Married
Address: Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.   
Tel: 0511 8002258, 09155199598

Current position (August 2006)

1-      Assistant Professor of Pharmacology. Department of Pharmacology. Mashhad University of Medical Sciences, Mashhad, Iran.

2-      Faculty Member of  Pharmacological Research Centre of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

 

3-   Faculty Member, Medical Toxicology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.

 

4-       Faculty Member, Education & Development Department, School of Medicine, Mashhad University of Medical Sciences.

 

5- Member of Basic Research Council. School of Medicine,

6- Member of Basic Research Council of Mashhad University of Medical Sciences.

7-  Executive Member of Middle-Eastern Association for Cancer Research  (MEACR).

 
 Academic Background:
1- Curèrent position (August 2006)
Assistant Professor of Pharmacology. Mashhad University of Medical Sciences, Mashhad, Iran.
2- May 2006
Receiving Ph.D. degree from the Department of Pharmacology at Iran University of Medical Sciences Faculty of Medicine, Tehran, Iran.
3- July 2005 until December 2005 
Visiting researcher in the laboratory of Dr. Peter. Hersey at University of Newcastle, Australia.
4- January 2001
Beginning a Ph.D. program in the Department of Pharmacology at Iran University of Medical Sciences Faculty of Medicine, Tehran, Iran.
5- September 1992 until September 2000
Medical Doctor program at Mashhad University of Medical Sciences Faculty of Medicine, Mashhad, Iran.

 
 Awards and Ranks:

2009

First Rank in the “Best Researcher Award” at Mashhad University of Medical Sciences

 

2009

Best Idea in Medical education in “Shahid Motahhari Medical Education Festival” at Mashhad University of Medical Sciences

 

2005
Iranian Ministry of Health and Medical Education research travel grant for a 6‑month stay as part of my Ph.D. program in the laboratory of Dr. P. Hersey  at University of Newcastle,  Australia

2000
National Ph.D. Entrance Exam (Pharmacology), 1st rank among 200 participants.

 

1998

Third Rank in internship exam at Mashhad University of Medical Sciences.

.
 Published Original Papers:

1- Sharifi AM, Mousavi SH.  Larijani B. Study of interaction between nitric oxide and ACE activity in STZ-induced diabetic rats: role of insulin. Pharmacol Res. 2004 Sep;50(3):261-6.

2- Sharifi AM, Mousavi SH , Bakhshayesh M, Tehrani FK, Mahmoudian M, Oryan S. Study of correlation between lead-induced cytotoxicity and nitric oxide production in PC12 cells. Toxicol Lett. 2005 Dec 30;160(1):43-8. Epub 2005 Jul 21.

3- Sharifi AM, Mousavi SH , Larijani B. Study of correlation between systolic blood pressure and angiotensin converting enzyme (ACE) activity in STZ induced diabetic rats. Iranian Journal of Diabetes and Lipid Disorders. 2005 4(2): 7-13

4- Sharifi AM, Mousavi SH , Larijani B. Effect of insulin on serum and tissue ACE activity in diabetic rats. Iranian Journal of Diabetes and Lipid Disorders. 2004 3(2): 195-200

5- Farhadi M, Parivar K, Sharifi AM, Zeinali S, Mousavi SH , Bakhshayesh M. Effect of different glucose concentration on PC12 cells apoptosis: role of Bax and Bcl-2 proteins. Medical Sciences Journal of Islamic Azad University. 2005 15(4), 161-166

6-Fata AM , Bloorsaz M, Mousavi SH . Porbadakhshan M. Comparison the efficacy of griseofulvin and miconazole (alone and together) on 100 patients suffering from dermatophytosis in Mashhad.. Medical Journal of Mashhad University of Medical Sciences 2001, 44 (72), 36-41

7- Mousavi SH *, Zhang XD , Sharifi AM and Hersey P. Study of Rose Bengal-Induced Cell Death in Melanoma Cells in the Absence of Light. Iranian Journal of Basic Medical Sciences. 2006. 9 (3), 216-222

8- Fata AM, Tavasoli F, Mousavi SH , EbrahimBoshra – Al- AMin Sh. Efficacy of Clotrimazole, Nystatin and Povidone Iodine in Traetment of Patients Suffering from Vaginal Candidiasis. Medical Journal of Mashhad University of Medical Sciences. .. .2007. 49 (94)

9- Sharifi AM, Mousavi SH , Farhadi M, Larijani B. Study of high glucose-induced apoptosis in PC12 cells: role of bax protein. J Pharmacol Sci. 2007 Jul;104(3):258-62.

10- Mousavi SH *, and Hersey P. Role of caspases and reactive oxygen species in rose bengal-induced toxicity in melanoma cells. Iranian Journal of Basic Medical Sciences. 2007 10 (2), 210-215

11- Sharifi AM, Mousavi SH Study of Lead-Induced Toxicity in PC12 Cells: Role of Apoptosis. In Press in Toxicology Mechanisms and Methods. 2008 18 1-5
 
12- Balali-Mood M, Mousavi SH, Balali-Mood B. Chronic health effects of sulfur mustard exposure with special reference to Iranian veterans' Emerging Health Threats. Emerging Health Threats. 2008, 1:e2, 1-12 

13- Mousavi SH *, Moosavi SH,  Lysosome: as a proposed target for rose bengal in inducing cell death in melanoma cells. Irn J Med Hypotheses Ideas.. 2008, 2:12

14.  Alavian SM, Moosavi SH, Mousavi SH , Azizi B, Akbari H, Study of Admission Rate of Hepatitis B Surface Antigen Positive Patients in 50 Dentistry Centers in Tehran (Spring 2003). Hepatitis Monthly 2007; 8(1), 67-69

15- Tavakkol Afshari J, Brook A, Mousavi SH *. Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food Chem Toxicol, 2008 Nov; 46, 3443-3447. 

16-  Mousavi SH *, Tayarani-Najaran Z, Hersey P. Apoptosis: from Signalling Pathways to Therapeutic Tools. Iranian Journal of Basic Medical Sciences. Vol. 11, No. 3, Autumn 2008, 121-142                    

17 Mousavi SH *, Tavakkol Afshari J, Brook A, Jafari Anarkooli I. Direct toxicity of rose bengal in MCF-7 cell line: Role of apoptosis. Food Chem Toxicol, 2009. 47(4):855-9.

18- Mousavi SH *, Tavakkol Afshari J, Brook A, Jafari Anarkooli I. Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells.Food Chem Toxicol, 2009. Aug;47(8):1909-13

19- Mousavi SH *, Tavakkol Afshari J, Brook A. Study of cytotoxic effects of saffron in MCF-7 cells: role of apoptosis. Iranian Journal of Pharmaceutical Sciences (IJPS). 2008: 4(4): 263-268

20- Mousavi SH , Tayarani-Najaran Z, Parsaee H.  Protective effect of saffron extract and crocin on reactive oxygen species-mediated high glucose-induced toxicity in PC12 cells. Cell Mol Neurobiol 2009. Aug 27

21- Mousavi SH , Zamani TR SH, Siadat Z, Mahmoudi  M.Study the anti-inflammatory effect of Rose Bengal in LPS-activated macrophages in dark. Journal of Birjand University of Medical Sciences. 2009; 16 (2): 10-17. 

22- Tayarani-Najaran Z, Mousavi SH , Asili J, Emami SA. Growth-inhibitory effect of Scutellaria lindbergii in human cancer cell lines. Food Chem Toxicol. 2009 Nov 20.  

23- Tayarani-Najaran Z, Asili J, Emami SA. Mousavi SH * Analyzing cytotoxic and apoptogenic properties of Scutellaria litwinowii root extract on cancer cell lines. Evidence Based Complementray and Altenative Medicine (Ecam). Dec 2009  

24- Mousavi SH, Tayarani-Najaran Z, Sadeghnia HR. Protective effect of Nigella sativa extract and thymoquinone on serum/glucose deprivation-induced PC12 cells death. Cell Mol Neurobiol. Jan 2010

25- Sharifi AM, Mousavi SH, Jorjani M. Effect of Chronic Lead Exposure on Pro-Apoptotic Bax and Anti-Apoptotic Bcl-2 Protein Expression in Rat Hippocampus In Vivo. Cell Mol Neurobiol. 2010 Feb

26- Tayarani-Najaran, Z, Parsaee H, Hoseini A, Mousavi SH*. Study of noscapine-induced cell death in hepatocellular carcinoma cell line. Pharmacologyonline. Volume 3, September 2009, Pages 522-530

27-Tayarani-Najaran Z, Sadeghnia HR, Asghari M,  Mousavi SH*. Neuroprotective effect of Nigella sativa hydro alcoholic extract on serum/glucose deprivation induced PC12 cells death. Physiology and Pharmacology, 2009, 13 (3), 263 – 270.   

 

28- M. Bakavoli, M. Rahimizadeh, A. Shiri, M. Akbarzadeh, Mousavi SH, Z. Tayarani-Najaran, Z, H. Atapour-Mashhad, M. Nikpour, J. Synthesis of New Derivatives of 3-Aryl-1,5-dimethyl-1H- [1,2,4]triazolo[40,30:1,2]pyrimido[4,5-e][1,3,4]oxadiazines as

Potential  Antiproliferative Agents J. Heterocycl. Chem., 2010,

 

29- M. Bakavoli, M. Rahimizadeh, A. Shiri, M. Akbarzadeh, Mousavi SH, H. Atapour-Mashhad, Tayarani-Najaran, Z,  Synthesis and anticancer evaluation of new derivatives of 3-phenyl-1,5- dimethyl-1H-[1,2,4]triazolo[4’,3’:1,2]pyrimido[4,5-e][1,3,4]oxadiazine J. Chem. Res., 2010, 2010 JULY, 403–406.

30-  Atapour-Mashhad H, Tayarani-Najaran Z,  Davoodnia A, Moloudi R.  Mousavi SH*. Antitumor activity of novel pyrrolo[2,3-d]pyrimidin-4-ones. Drug and Chemical Toxicology, 2011; 34(3): 271–276.

31 Mehri S, Abnous K, Mousavi SH, Shariaty VM, Hosseinzadeh H. Neuroprotective Effect of Crocin on Acrylamide-induced Cytotoxicity in PC12 cells. Cell Mol Neurobiol. 2011 Sep 7

32- Mousavi SH, Moallem SA, Mehri S, Shahsavand S, Nassirli H, Malaekeh-Nikouei B. Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form. Pharm Biol. 2011 Oct;49(10):1039-45.

 

33- Study of cytotoxic properties of Rosa damascena extract in human cervix carcinoma cell line. Amir Zamiri-Akhlaghi1, Hasan Rakhshandeh1, Zahra Tayarani-Najaran1, Mousavi SH*. Avicenna Journal of Phytomedicine. Vol. 1, No. 2, Autumn 2011, 74-77

 

34- Tayarani-Najaran Z, Mousavi SH, Vahdati-Mashhadian N, Emami SA, Parsaee H. Scutellaria litwinowii induces apoptosis through both extrinsic and intrinsic apoptotic pathways in human promyelocytic leukemia cells. Nutr Cancer. 2012;64(1):80-8. 2011 Nov 18.

 

35- Afsharzadeh M, Tayarani-Najaran Z, Zare A,Mousavi SH*. Protective Effect of Scutellaria litwinowii Extract on Serum/Glucose-Deprived Cultured PC12 Cells and Determining the Role of Reactive Oxygen Species. Journal of Toxicology. 2012

36- Tayarani-Najaran Z, Asili J, Parsaee H, Mousavi SH, Vadati Mashhadian N, Mirzaee A, Emami SH. Wogonin and neobaicalein from Scutellaria litwinowii roots are apoptotic for HeLa cells. Rev. Bras. Farmacogn. / Braz. J. Pharmacogn. 2012

 
*  Corresponding  Author

 Presentations:

Mousavi SH*, Zhang XD, Wachter E , Hersey P. ُStudy of in vitro and clinical effects of Rose Bengal-induced cell death in melanoma 18th Iranaian Congress of Physiology & Pharmacology, August 2007, Mashhad, Iran (Oral presentation).

Mousavi SH*., Sharifi A.M, Bakhshayesh M Investigation of lead-induced neurotoxicity in PC12 cell: Role of Nitric Oxide & Apoptosis. 6th annual congress of Asia Pacific Association of Medical Toxicity, Bangkok, Thailand, December2007.(Oral presentation).

Sharifi AM , Mousavi SH* , Larijani B. Study of interaction between nitric oxide and ACE activity in STZ-induced diabetic rats. 7th International Congress of Endocrine disorder. Tehran, Iran, October ,2004. (Oral presentation).

Mousavi SH, Zhang X, Gillespie S, Wachter E, Hersey P*. Rose Bengal induces dual modes of cell death in melanoma cells and has clinical activity against melanoma. Melanoma Congress. Holland . September 2006 (Oral presentation).
 

Mousavi SH*, Tavakol Afshari J , Brook A, Jafari I. Study of saffron-induced apoptosis in MCF-7 cells: role of caspase and Bax protein. 4th Life Science postgraduate Conference, 18-20th June 2008, USM, Malaysia (Oral presentation).

 

Mousavi SH*, Direct toxicity of rose bengal in MCF-7 cell line: Role of apoptosis and Bax protein. 11th Iranian Pharmaceutical Sciences Conference (IPSC2008)  Iran, 18-21 August, 2008. (Oral presentation).

Mousavi SH*, Shahsavand SH, Mehri  S, Moallem SA,  Malaekeh B. .Study of cytotoxic and apoptogenic properties of nano-liposomes forms of crocin compared to crocin in various human cancer cell lines. 11 th    International Conference on Advanced Materials (ICAM). Brazil, September 2009.  (Oral presentation)

Mousavi SH* Tavakol Afshari J , Brook A.  Saffron: as a promising medicinal plant in breast and cervix cancer treatment. The First International of Gynecology Oncology Congress under the auspices of IGCS.   Mashhad . 10 - 12 Oct. 2008. (Oral presentation)

Mousavi SH*,.Sharifi AM, Bakhshayesh m, Tehrani F, Oryan S, Mahmoudian M. Study of Correlation between Lead-Induced Toxicity and Nitric Oxide Production in PC12 cells.17th Iranian Congress of Physiology & Pharmacology, October 2005 Kerman, Iran

Mousavi SH*,.Sharifi AM. Investigation of the protective effect of garlic extract on glucose-induced cytotoxicity in PC12 cells: Role of Apoptosis. IUPHAR 2006, China

Sharifi AM, Mousavi SH*., Bakhshayesh Masoomeh . Study of lead-induced-apoptosis in PC12 cell. The 9th Iranian Congress of Toxicology, May 2007, shiraz, Iran

Tavakol Afshari J , Mousavi SH , Brook A. Study of Rose Bengal-induced cytotoxicity and apoptosis in breast cancer cell line(MCF-7). 18th Iranaian Congress of Physiology & Pharmacology, August 2007, Mashhad, Iran

Brook A, Mousavi SH , Tavakol Afshari. Study of aqueous and etanolic saffron extract-induced cytotoxicity and apoptosis in MCF-7 cell lines. 18th Iranaian Congress of Physiology & Pharmacology, August 2007, Mashhad, Iran

Zamani Taghizadeh Rabe Sh, Mousavi SH, Mahmoudi M. Study of anti-inflammatory effect of Rose bengal in inflammatory macrophages18th Iranaian Congress of Physiology & Pharmacology, August 2007, Mashhad, Iran

Mousavi SH*, Tavakol Afshari J , Brook A Study of cytotoxic and apoptogenic properties of different saffron extracts in human cancer cells. 6th annual congress of Asia Pacific Association of Medical Toxicity, Bangkok, Thailand, December 2007
 

Mousavi SH*, Parsaee H, Tayrani Z. Study of correlation between glucose-induced cytotoxicity and reactive oxygen species production in pc12 cells. The 10th Iranian Congress of Toxicology, May 2009, Tehran, Iran

 

Mousavi SH*, Shahsavand SH, Mehri  S, Moallem SA,  Malaekeh B. Assessment of cytotoxic and apoptogenic properties of safranal and its nanoliposoms in various cancer cell lines. 11 th    International Conference on Advanced Materials (ICAM). Brazil, September 2009.

سید هادی موسوی، رضا افشاری، محمد تقی رجبی مشهدی. راه اندازی دو واحد درس "درمان شناسی و نسخه نویسی" برای گروه هدف کارورزان دانشکده پزشکی مشهد: گامی بسوی تلفیق علوم پایه و بالینی. دهمین کنگره کشوری آموزش علوم پزشکی – شیراز اردیبهشت 1388

 

* Presenting Author

 

Accepted Projects :

1- Study of Saffron Hydroalcoholic Extract  Effects on Glucose-Induced Neurotoxicity in PC12 Cells: Role of Apoptosis & ROS. Code:85344(Finished)

2- Study of aqueous saffron extract-induced cytotoxicity and  apoptosis in HepG2, MCF-7 and HeLa cell lines. Code:85419 (Finished)

 

3- Study of Rose Bengal effect on cell cytotoxicity, nitric oxide production & inducible nitric oxide synthase expression in macrophages  Code: 85497 (Finished)

4- Study of Rose Bengal-induced cytotoxicity and  apoptosis in breast cancer cell line. Code:85500 (Finished).

5- Study of Noscapine-induced Cytotoxicity and Apoptosis in HepG2 cell lines. Code: 186325

6-Study of saffron stigma effects on quality of life and response to treatment in patients suffering from liver metastases. A clinical trial Code: 87432.

7- An investigation of saffron effect on serum lipids profile and serum antibody titres to Heat Shock proteins 60,65,70 in subjects with dyslipidemia. Accepted by INSFصندوق حمایت از پژوهشگران کشور. Code: 86072.24.

8-  Protective effect of Nigella sativa seeds oil and thymoquinone, its active constituent, on serum/glucose deprivation-induced pc12 cells death.  Code: 87519

9- Study of cytotoxic and apoptogenic properties of crocin, safranal and their nano-liposome's  in some cancer cell lines. Code: 86534 (Finished)

11- Protective effect of Scutellaria litwinowii extract on serum/glucose deprivation-induced pc12 cells death. Code:88406

 

 
 
 Technical Skills:
Cell culture
Cytotoxicity assay (MTT, WST,…)
Assays of apoptosis & necrosis
Protein extraction, DNA extraction
Western blotting
Flow cytometry:
Assay of mitochondrial membrane potential by flow cytometry
Assay of intracellular reactive oxygen specious (ROS) by flow cytometry
Assay of cell cycle by flow cytometry
Assay of apoptosis by flow cytometry
HPLC (Assay of ACE activity)
Assay of Nitric Oxide